This paper deals with cutaneous eruptions not quite conforming with any well known dermatologic entity. The main feature common to all these conditions was their response to parenteral liver therapy, which suggested that they were due to a deficiency of the vitamin B complex. In none of the cases observed was a diagnosis of pellagra permitted, since the cutaneous manifestations were not typical of this disease, nor were they associated with lesions of the mucous membranes of the mouth, gastrointestinal disturbances or mental symptoms. Therefore, this classification as nonpellagrous eruptions due to deficiency of the vitamin B complex seemed justified.
In recent years chemical investigations of the vitamin B complex, studies on intracellular enzymes and their relations to vitamins and observations on experimental deficiencies in animals have thrown much light on the deficiency diseases observed in man. Although the field is large and the literature inexhaustible, it seems necessary to
GROSS P. NONPELLAGROUS ERUPTIONS DUE TO DEFICIENCY OF VITAMIN B COMPLEX. Arch Derm Syphilol. 1941;43(3):504–531. doi:10.1001/archderm.1941.01490210072008
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