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Toxic states are now known to occur for other reasons than the simple ingestion or elaboration of some definite poisons. Deficiency states of nutrition may give the appearances of acute and chronic poisoning. Ever since the first crude experiments, such as the extirpation of the parathyroid glands, it has been known that toxic states may be induced by lack of glandular hormones. Toxic states are now known to occur as the result of noxious agents interfering with some nutritive agents, such as thiamine and nicotinic acid, in their enzymic relations and activities. It is the feeling here that the toxic states in patients with disseminated lupus erythematosus represent deficiency states or interferences with normal processes which amount to and simulate a lack of necessary physiologic materials.
The treatment of these toxic states in patients with disseminate lupus erythematosus is ineffective, and almost all the patients die soon or during a
CORNBLEET T. ACUTE AND SUBACUTE DISSEMINATED LUPUS ERYTHEMATOSUS: TREATMENT WITH LIVER EXTRACT. Arch Derm Syphilol. 1941;43(5):829–832. doi:10.1001/archderm.1941.01490230069009
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