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June 1941


Author Affiliations


From the Department of Dermatology and Syphilology, University of Louisville School of Medicine, Louisville, Ky.

Arch Derm Syphilol. 1941;43(6):971-979. doi:10.1001/archderm.1941.01490240051007

In 1930 Gustav Hopf1 presented before the Hamburg-Altona Dermatological Association 2 patients with unusual wartlike keratoses on the dorsa of the hands and feet. This dermatosis did not fall into any hitherto known classification. To this unusual condition Hopf gave the name acrokeratosis verruciformis. In 19332 he reported 4 additional cases. In his first case the lesions were limited to the backs of the hands, whereas in his second case there were similar lesions on the dorsa of the hands and feet, with some involvement also of the palms and the flexor surfaces of the fingers, wrists and forearms. The lesions on the dorsal surfaces consisted of verrucoid lichenoid polygonal papules not unlike flat warts, varying in size from that of a millet seed to that of a lentil. They were of firm consistency and varied in color from that of normal skin to reddish brown. Nearer the