Hamblen, Arena and Cuyler1 studied the output of urinary steroids which they classified as androgen in a case of Hand-Schüller-Christian disease. They found values ten times as large as the normal ones and felt that this increase was related to the general disturbance of lipoid metabolism rather than to an excessive activity of the gonads or of the adrenal cortex. Their patient, a male infant, did not excrete any sodium pregnandiol glucuronidate, a metabolite of secretion from the corpus luteum. After reading this report, we decided to assay the urine of a number of subjects with diseases of the skin classed as lipoidoses. This decision was based on the hypothesis that a relation exists between Hand-Schüller-Christian disease and at least some of the lipoidoses. This, however, is still a debatable subject, although cases of mixed varieties and transition states between have been reported and presented before various dermatologic groups.
CORNBLEET T, BARNES B. ANDROGEN AND THE XANTHOMATOSES. Arch Derm Syphilol. 1941;44(2):248–250. doi:10.1001/archderm.1941.01500020103010
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