Medical literature is now replete with reports of the administration of sulfanilamide and its derivatives in various diseases, largely those in which cocci or allied organisms have been proved a causative factor. Hughes1 has recently published an excellent bibliography and a brief review of the treatment of multiple dermatologic conditions with sulfanilamide. His review, however, reveals that the use of this marvelous drug, with but few exceptions, has been limited to its administration by mouth, hypodermically or intravenously. The exceptions are its use by certain physicians as a dusting powder on open infected wounds or ulcers.
After reviewing Hughes's citations and those of others, I have failed to find that sulfanilamide has been applied locally in solution, doubtless for the reason that according to manufacturing chemists sulfanilamide is soluble only to approximately 0.8 per cent in water, although it is much more soluble in alcohol or glycerin.