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August 1941


Arch Derm Syphilol. 1941;44(2):287-296. doi:10.1001/archderm.1941.01500020142021

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Argyria. Presented by Dr. Isadore Rosen.  J. F., a girl aged 7 years, came to the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital on Jan. 13, 1941 because of discoloration of the conjunctivas and of the skin of the nose.The history revealed the frequent application of 10 per cent mild protein silver (argyrol) to the nose and eyes by the mother every time the patient had a cold. These instillations have taken place since the age of 1 year. Three years ago attention was called to this pigmentation by physicians, but no instructions were given as to the discontinuation of administration of the mild protein silver, which has been continued until the present.The conjunctivas are of a peculiar slate color. Similar pigmentation is on the sides of the nose and on the hard palate.

DISCUSSION  Dr. Max Scheer: Nothing can be done

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