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September 1941


Arch Derm Syphilol. 1941;44(3):467. doi:10.1001/archderm.1941.01500030149019

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To the Editor:—  In the June issue of the Archives of Dermatology and Syphilology (43:992, 1941) is an article by Glicklich and Sherman entitled "Toxic Effects of Sulfathiazole Used in Treatment of Chancroidal Infection," describing serious manifestations which occurred when 6 Gm. of sulfathiazole was administered daily for seven days and, after a short interval when treatment was suspended owing to toxic manifestations, 1 Gm. every six hours was given for a short period before the patient's condition required discontinuance of administration of sulfathiazole.It may be pertinent to note that 6 Gm. per day is about three times and 4 Gm. per day (1 Gm. every six hours) about twice the necessary therapeutic dose of sulfathiazole. It is therefore not surprising that serious toxic manifestations occurred. The experience of Glicklich and Sherman should not discourage physicians in the use of sulfathiazole in proper doses. Chancroid yields surely and

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