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October 1941


Arch Derm Syphilol. 1941;44(4):588-599. doi:10.1001/archderm.1941.01500040043004

The subject of argyria has been reviewed in a recent monograph by one of us (W. R. H.) and Pillsbury.1 We wish to present briefly the clinical data of 68 additional cases of generalized argyria observed at the Mayo Clinic. In 17 of the cases, specimens of skin were removed for biopsy. We wish to emphasize the importance of histologic study in confirming the diagnosis of argyria and in differentiating argyria from other cutaneous pigmentations, especially those due to other heavy metals.

CLINICAL DATA  In the twenty-five years from 1915 to 1939 inclusive, 68 persons who had generalized argyria were seen at the Mayo Clinic, 41 of whom came after 1930. Females were more numerous than males in this series, in a ratio of 7:4. At the time of the first examination the youngest person was 6 years of age and the oldest 78. Two thirds, or 44, of

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