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Article
November 1941

TRICHOPHYTIN: II. THE APPARENT SEPARATION OF THE SKIN-REACTIVE FACTOR FROM THE THERAPEUTIC PRINCIPLE IN TRICHOPHYTIN

Author Affiliations

NEW YORK

From the Laboratories and Service of Dr. Isadore Rosen, Mount Sinai Hospital, and from the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital.

Arch Derm Syphilol. 1941;44(5):816-836. doi:10.1001/archderm.1941.01500050046005
Abstract

In a previous communication1 it was shown that Trichophyton gypseum was capable of producing a more alkaline pH in Sabouraud's bouillon when grown on a medium with an initial pH of 4.0 to 8.0. At an initial pH of 9.0 to 10.0 the organism acidified the medium. There was occasionally acidification in buffered solutions which had an initial pH of 7.0. At the end of variable periods of growth, approximately seventy-five to eighty days, the hydrogen ion concentration would finally become stabilized at a pH of 8.3 to 8.6.

We were able to demonstrate in experiments embodied in a recent paper2 that the component of trichophytin capable of eliciting a positive reaction to a cutaneous test was found in the bouillon itself as well as in the pellicle of a culture in Sabouraud's bouillon.

A number of observers have maintained that this skin-reactive

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