During the past three years specific oleoresins have been administered intramuscularly or orally to some 40 persons who suffered recurrent seasonal dermatitis from contact with one or more allergenic weeds.
Because of unsatisfactory clinical results, intramuscular administration of the excitant was discontinued after one season. The severity of local reactions prevented injection of the antigenic oils except in high dilutions. A study of the case records shows that the maximum amount of oil administered to a single patient during an entire season was equivalent to less than 0.4 cc. of the solvent-free specific oleoresin. If persons were willing to submit to daily multiple injections, clinical results would probably equal those obtained from oral therapy. None of my patients has submitted to even semiweekly injections of the oil for nine to ten months, the period during which oral therapy has usually been administered daily.
Satisfactory clinical results were obtained in approximately
SHELMIRE B. HYPOSENSITIZATION TO POISON IVY. Arch Derm Syphilol. 1941;44(6):983–998. doi:10.1001/archderm.1941.01500060002001
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