Since 1925 over 1,000 syphilitic patients have received therapeutic malaria at the University Hospital. Twenty-nine patients died as a result of this treatment—a mortality rate of 2.8 per cent. An analysis of the deaths discloses that peripheral circulatory collapse accounted for 12 (41 per cent); pneumonia, 5 (17 per cent); hyperpyrexia, 5 (17 per cent); suicide, 2 (7 per cent), and erysipelas, vascular accident (cerebral thrombosis), bleeding duodenal ulcer, ruptured spleen and respiratory failure, 1 (3 per cent) each.1
Before the induction of malaria, patients should be thoroughly examined with an evaluation of their physical ability to withstand this treatment. It is impossible to formulate definite criteria that will apply to every case. Generally speaking, one should be cautious in the selection of patients but should not lose sight of the serious nature of the disease to be treated, thereby omitting the treatment which is likely to have the
WILE UJ, MUNDT LK. AVOIDANCE OF FATAL COMPLICATIONS IN THERAPEUTIC MALARIA. Arch Derm Syphilol. 1941;44(6):1078–1081. doi:10.1001/archderm.1941.01500060099008
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