There are few drugs or chemicals which qualify as practical fungicides. Therefore, in the treatment of many fungous diseases chief reliance is placed on the natural resistance of the body, the use of keratolytics, irritants or soothing agents and occasionally the administration of roentgen rays, the scheme of treatment depending considerably on the species of invading fungus.
Because of this lack of available specific treatment and because sulfanilamide and its derivatives have proved capable of selective cure of a diverse number of conditions, it was thought important to ascertain their effect on fungi.
The following compounds were available for testing: sulfanilamide, sodium sulfapyridine (sodium 2-[paraaminobenzenesulfonamido]-pyridine), sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole), sodium sulfathiazole, sulfadiazine (2-[paraaminobenzenesulfonamido]-pyrimidine) and sodium sulfadiazine.Strains of Trichophyton gypseum and of Monilia albicans were used.
Measured quantities of ordinary isolation agar were melted, and the drugs in various concentrations were added. The insolubility of most of the compounds
LEWIS GM, HOPPER ME. EFFECT OF SULFANILAMIDE AND ITS DERIVATIVES ON FUNGI: PRELIMINARY IN VITRO EXPERIMENTS. Arch Derm Syphilol. 1941;44(6):1101–1103. doi:10.1001/archderm.1941.01500060122012
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