The peculiar ability of the skin to form fibrous tissue and its accumulation in fibrous nodules led us to study the various conditions in which such changes occur and endeavor to find the reason for their occurrence. Nodules appear after trauma and with such general systemic diseases as syphilis, yaws, leprosy, scleroderma, rheumatic fever, rheumatoid arthritis and acrodermatitis chronica atrophicans. Fibrous tissue is also seen in the harmless subepidermal fibrosis and in a fibrous accumulation over the knuckles called knuckle pads.
What causes this fibrous reaction? Why do the nodules so often occur over joints? Why do they occur with systemic diseases? Are there any clinical and histologic differences in the various lesions? Can long-continued oft repeated slight trauma be the only causative factor or is there a fibrotic diathesis in persons who have these lesions?
Juxta-articular nodes are found in both syphilis and yaws. They were first described by
SWEITZER SE, WINER LH. FIBROTIC NODULES OF THE SKIN. Arch Derm Syphilol. 1942;45(2):315–327. doi:10.1001/archderm.1942.01500080059004
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