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Mrs. P. H., aged 40, came to my office on April 9, 1941, complaining of a sore on the upper lip. She stated that it had started as a "small pimple" four weeks previously and had gradually increased in size.
Patient with granuloma pyogenicum before (A) and after (B) treatment with sulfathiazole.
Examination showed a well circumscribed, slightly elevated soft granulomatous lesion, 2 cm. in diameter. It was situated on the middle of the upper lip. The lesion was covered with a thin crust, which was easily removed; the lesion then bled freely. The surrounding tissue was normal. There was a slight enlargement of the cervical glands. The temperature was 99 F.
The patient was admitted to the hospital for observation during treatment. Sixty grains (4 Gm.) of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) was given every twenty-four hours for four days. The dose was then decreased to 30 grains (2 Gm.) every twenty-four
Allison JR. GRANULOMA PYOGENICUM TREATED WITH SULFATHIAZOLE: Report of a Case. Arch Derm Syphilol. 1942;45(3):579. doi:10.1001/archderm.1942.01500090126013
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