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Article
April 1942

SENSITIVITY TO PROTAMINE ZINC INSULIN

Arch Derm Syphilol. 1942;45(4):694-696. doi:10.1001/archderm.1942.01500100055006
Abstract

Protamine zinc insulin has been used in treatment in thousands of cases of diabetes mellitus. A survey of the American literature of the past five years reveals but a single report1 of a case of allergy to this drug. It is this infrequent incidence of sensitivity to protamine zinc insulin that has prompted my presenting the following case.

REPORT OF A CASE  A 56 year old white man presented an itching eruption of the arms, the dorsa of the hands and the palms of one month's duration. The history failed to reveal contact with external irritants. His general health had been good until about three years previously, when his physician discovered that he had mild diabetes mellitus. This condition was controlled by diet alone until about two months before the development of the eruption, when he was required to use 8 units of protamine zinc insulin daily. From the

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