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Article
May 1942

BISMUTH ETHYL CAMPHORATE: ITS USE IN TWENTY-SIX CASES OF EARLY SYPHILIS

Author Affiliations

DALLAS, TEXAS

From the Dallas Syphilis and Venereal Disease Clinic, Department of Health, Parkland Hospital.

Arch Derm Syphilol. 1942;45(5):876-884. doi:10.1001/archderm.1942.01500110036003
Abstract

The therapeutic value of a drug used in the treatment of syphilis is dependent on certain well known factors, of which the most important are (1) the spirocheticidal effectiveness of the preparation, on which in turn depends the rapidity of the healing of the lesions, (2) the serologic response of the patient and (3) the tolerance of the patient for the drug from the standpoint of immediate and delayed local and systemic reactions. These properties can best be determined in cases of early syphilis (primary and secondary) and in animal syphilis.

Previous studies have been made on the therapeutic effectiveness of bismuth ethyl camphorate. Thurmon1 found this preparation, which is a liposoluble bismuth salt of ethyl camphoric acid, having 23.47 per cent bismuth (40 mg. elemental bismuth per cubic centimeter), to be an extremely valuable adjunct to the arsphenamines in the treatment of syphilis. In a later study, Thurmon

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