Ichthammol is a sulfonated bitumen of complex structure. As early as 1883 Baumann and Schotten,1 after purely chemical research, drew up an empiric formula for a sulfone compound, ammonium ichthosulfonate, which they called ichthyol (sulfonated bitumen N. F. V; ichthammol N. F. VI). Three years later Unna2 published the first comprehensive study on its clinical application. He recommended the compound primarily for the therapy of dermatoses, but he also mentioned that it was useful when administered internally for treating gout and rheumatic conditions. It was first used in gynecologic practice by Freund3 in 1890. Shortly thereafter Neisser4 and Jadassohn5 recommended it for the treatment of gonorrhea. More recently Scheibler6 and Scheibler and Rettig7 showed that its therapeutic effect is due to its sulfur-containing compounds, principally thiophene homologues. In 1931 Pincussen8 stated that one action of the substance is to effect a change
STEWART CD, GOLDMAN M, OBERMAYER ME. HISTOLOGIC EVALUATION OF THE EFFECTS OF ICHTHAMMOL. Arch Derm Syphilol. 1942;45(5):933–940. doi:10.1001/archderm.1942.01500110093010
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.