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May 1942


Arch Derm Syphilol. 1942;45(5):1015-1022. doi:10.1001/archderm.1942.01500110175024

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A Case for Diagnosis (Chrysiasis?). Presented by Dr. Adolph Rostenberg.  A patient aged 35, a housewife, was taken ill about two years ago with a severe attack of polyarthritis, for which she received a variety of internal medication. In April 1941 her physician instituted a course of intramuscular injections of gold sodium thiosulfate, giving her a total of fourteen injections at weekly intervals. After the sixth injection her eyelids became swollen and itchy. At the same time she began to complain about irregular uterine bleeding. Following the eighth injection an eruption appeared on the buttocks and legs accompanied by severe itching. The treatment was continued until a generalized desquamating dermatitis developed.When first seen on August 5, the patient presented a severe generalized exfoliative dermatitis. After eight intravenous injections of calcium thiosulfate and local medication the eruption began to clear and the skin began to assume a normal appearance. At

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