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The difficult task of attempting to explain the importance of natural resistance of the host in determining the occurrence and outcome of infection has been undertaken by the authors. They distinguish between natural and acquired resistance. Acquired immunity depends on the presence of antibodies and on an altered state of the tissues in their reaction to reinfection. Natural resistance has for many years been attributed to differences in "constitution." It is now apparent that while heredity is a factor a definite part of the difference in "constitution" is due to the functional activity of the glands of internal secretion. Recent knowledge in the field of nutrition, especially among the vitamins, shows these substances to be closely related to the hormones in many of their physiologic activities, including those related to natural resistance and susceptibility.
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Natural Resistance and Clinical Medicine. Arch Derm Syphilol. 1942;45(5):1035–1036. doi:10.1001/archderm.1942.01500110195029
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