The diagnostic value of cutaneous lesions in the province of internal medicine is aptly illustrated by the dermatosis entitled acanthosis nigricans. This disease is uncommon, but it is so frequently associated with carcinoma of the internal organs that its positive diagnosis may be considered an indication for exploratory laparotomy.
In the adult or malignant form of acanthosis nigricans, the usual concomitant growth is a carcinoma of the stomach. The association of this pigmentary disorder with a malignant growth of the lungs has been reported in only 2 cases.
REPORT OF A CASE
I. P., a white man aged 59, was admitted to the Beth Israel Hospital in January 1938 because of a productive cough associated with vague pains in the chest. These symptoms had been present since July 1936. In November 1937 the patient's cough had increased in intensity, and he was productive of a cupful of yellow, tenacious and
LEVIN OL, BEHRMAN HT. ACANTHOSIS NIGRICANS ASSOCIATED WITH CARCINOMA OF THE LUNG. Arch Derm Syphilol. 1942;46(1):54–58. doi:10.1001/archderm.1942.01500130057004
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