During the course of our study of the effects of treatment of senile vulvovaginitis, leukoplakia and kraurosis vulvae with estrogens, we observed the beneficial effect that the treatment had not only on the local lesions but on the pruritus which was usually present. In practically every case there was a diminution or disappearance of the itching and with it of the scratch marks and local irritation. This led us to believe that in at least some of the cases of senile pruritus the itching was caused by local or constitutional changes incidental to a sex hormone deficiency.
We decided to make an attempt to verify our belief by treating some of our elderly patients who suffered from pruritus with estrogens and androgens. Fortunately, we had the material at hand and proceeded to select our cases, but this was beset with numerous difficulties. Not all elderly persons with thin, dry and
FELDMAN S, POLLOCK J, ABARBANEL AR. TREATMENT OF SENILE PRURITUS WITH ANDROGENS AND ESTROGENS. Arch Derm Syphilol. 1942;46(1):112–127. doi:10.1001/archderm.1942.01500130115010
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