This study is a review of 31 cases of granuloma annulare which were observed at the Mayo Clinic between 1916 and July 1941. The purpose of this review was twofold. First, thorough study was made of material obtained for biopsy in 13 cases of granuloma annulare, and in this study an attempt was made to determine the essential characteristics which are necessary to the making of a diagnosis. Second, by correlation and evaluation of the clinical observations in 31 cases and the results of histologic study in 13 cases, we hope to present evidence which will assist in determining the role played by tuberculosis in the causation of granuloma annulare.
It has been generally accepted that the credit for the first description of this cutaneous disease should be ascribed to Colcott Fox,1 who, in 1895, reported a case of it under the name "ringed eruption on the