Epidermodysplasia verruciformis was described for the first time in 1922 by Lewandowsky and Lutz.1 Nine years later, in 1931, Mashkilleison2 collected 24 cases published in medical literature all over the world. In September 1939 Sullivan and Ellis3 reported 18 other cases observed, thus making a total of 42. We have no knowledge of any cases published in Brazil and believe ours are the first. According to the general revision made by Mashkilleison and Sullivan and Ellis, the cases of familial incidence published up to that time were those of Sézary and Lévy-Coblentz (father, brother and sister) and those of Masaki (3 sisters).
In the cases to be reported the patients were brother and sister whose parents were cousins; the lesions were generalized and appeared at the age of 9 years in both patients. The girl had localized lesions in the axillary fossae and on the external genitalia