The work reported in this paper was undertaken as part of a general investigation of the intensive treatment of early syphilis conducted by Dr. Evan W. Thomas and his co-workers at Bellevue Hospital, New York.1 The purposes of these studies were: (1) to observe the extent of individual variations in concentration of arsenic in the blood in response to fixed doses of mapharsen; (2) to study the influence of concomitant fever therapy, induced by typhoid vaccine, on the level of arsenic in the blood, and (3) to compare the concentrations of arsenic in the blood after use of the multiple injection method with those obtained after use of the continuous drip method as reported by Sobotka, Mann and Feldblau,2 working with Hyman, Chargin and Leifer at Mount Sinai Hospital, New York.
MATERIAL AND METHODS
The arsenic content of the blood of 31 patients with early syphilis was determined