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December 1942


Author Affiliations


From the Dermatological and Medical Clinics of the Massachusetts General Hospital and the Fatigue Laboratory, Harvard University.

Arch Derm Syphilol. 1942;46(6):800-823. doi:10.1001/archderm.1942.01500180020004

The purpose of this study is to trace the development of the concept of pemphigus as a clinical entity from earliest recorded times to the present. Cases described in past centuries and considered as instances of pemphigus by the authors at that time or by subsequent writers will be discussed. This diagnosis was frequently given in the past to conditions which now would not be called pemphigus because the concept of the disease has undergone considerable change. An attempt will be made in this study to discern, as accurately as possible, the correct diagnosis in the older cases. It is hoped by this method to establish with reasonable assurance the dates of the description of the first cases of pemphigus. The older reviews of the history of pemphigus are short and incomplete, and their value is impaired because the present concept of pemphigus is recent in origin. During the last

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