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January 1943


Author Affiliations


From the departments of Dermatology and Syphilology of the University of Pennsylvania and of the Woman's Medical College of Pennsylvania and the Philadelphia General Hospital.

Arch Derm Syphilol. 1943;47(1):58-73. doi:10.1001/archderm.1943.01500190061007

HISTORY  Jonathan Hutchinson1 in 1875 recorded what was probably the first clinical description of sarcoidosis; his patient had purplish nodular sharply circumscribed lesions on the fingers, forearms and legs, together with nontender swelling of one finger. Besnier2 in 1889 described a symptom complex consisting of nodular reddish blue lesions of the face and nose in conjunction with swellings of the fingers and gave it the name of lupus pernio. In 1897 and 1899 Boeck3 reported the first of his cases of "multiple benign sarcoid," considering this disease allied to the sarcoma group and confined to the skin. He later changed the name to benign miliary lupoid, when he recognized the resemblance of this condition to tuberculous processes.In 1902 Kienboeck described the cystic osseous changes of the fingers and toes found on roentgen examination, and Kreibich4 in 1904 first associated these with the cutaneous changes of

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