The therapeutic efficiency of any arsenical preparation for the treatment of syphilis is judged largely from the response of early syphilis (primary and secondary) to its use. In order to evaluate a new drug the most important factors to consider are: (1) the rapid control of infectiousness, (2) the healing of lesions, (3) the rate and permanence of serologic response, (4) the prevention of infectious or serologic relapse and progression of the disease, (5) low incidence of involvement of the central nervous system in early syphilis, (6) a beneficial effect on late syphilis and (7) a low incidence of untoward or toxic reactions. A drug which would meet these requirements would indeed be ideal.
Arsphenamine is, even today, the most active of the arsenical preparations in common use, and yet, because of the difficulties encountered in its administration and its untoward effects, it has been largely replaced by drugs which
LONG WE. TREATMENT OF SYPHILIS WITH PHENARSINE HYDROCHLORIDE: PRELIMINARY REPORT. Arch Derm Syphilol. 1943;47(2):226–234. doi:10.1001/archderm.1943.01500200070006
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