In 1941 we made a first report1 on the rapid treatment of early syphilis by a course of diurnal injections of mapharsen, either alone or combined with fever therapy. By June 1942 in Bellevue Hospital 829 such courses had been given. As 47 of those were retreatments of patients who either had not been cured by their first course or had been reinfected, we treated a total of 782 patients. Of these, 479 were male and 303 female, and 462 were Negroes, 283 white persons, 35 Puerto Ricans and 2 Chinese.
METHODS OF TREATMENT AND CHOICE OF PATIENTS
Originally we set out to give every patient a total of 1.2 Gm. of mapharsen. As we reported, we did not administer the drug by the intravenous drip method introduced by Chargin, Leifer and Hyman.2 Instead, we gave 0.06 Gm. of mapharsen intravenously every morning and evening for ten days.
THOMAS EW, WEXLER G. RAPID TREATMENT OF EARLY SYPHILIS: REPORT OF TWO HUNDRED AND EIGHTY TREATMENT COURSES WITH MAPHARSEN ALONE AND FIVE HUNDRED AND FORTY-NINE TREATMENT COURSES WITH MAPHARSEN COMBINED WITH FEVER. Arch Derm Syphilol. 1943;47(4):553–568. doi:10.1001/archderm.1943.01500220091008
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