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Article
April 1943

EVALUATION OF A FUNGICIDAL AGENT FOR FUNGOUS DISEASE OF THE FEET: A CONTROLLED HOSPITAL STUDY

Author Affiliations

CINCINNATI

From the Department of Dermatology and Syphilology and the Department of Bacteriology, University of Cincinnati College of Medicine, and the Cincinnati General Hospital.

Arch Derm Syphilol. 1943;47(4):569-573. doi:10.1001/archderm.1943.01500220107009
Abstract

This report is presented to show some of the difficulties encountered in attempting a controlled clinical study of a fungicidal agent. It is always difficult to determine, in a relatively short period, the true value of therapeutic agents for the treatment of fungous disease of the feet. The analysis is made usually by pure clinical observation, by laboratory findings or, what is more common, by a combined clinical and laboratory survey. Many of these studies are open to criticism because of the duration of the period of observation, lack of controls and lack of continued observation of patients during the test period.

In an effort to work out a controlled program for the study of a fungicide in the therapy of fungous infection of the feet the following plan was adopted: (1) continued hospital observation of the patient by different observers in different institutions; (2) use of one foot as

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