Kraurosis vulvae is a rare disease occurring about the time of the menopause or later. It is characterized by intense itching of the vulva and various stages of inflammation and leukoplakia of the labia minora, clitoris and vaginal orifice. The diseased tissue is brittle and consequently fissures readily. These fissures are tender and painful. The subsequent course of kraurosis vulvae is that of atrophy, leukokeratosis and eventually epitheliomatosis.
Kraurosis vulvae is chronic, is unresponsive to topical treatment and leads to serious complications. Cole stated the belief that kraurosis vulvae always eventuates in cancer if it continues sufficiently long. To date surgical intervention has been considered the best form of therapy. However, to be effective vulvectomy must be extensive, with subsequent loss of (sexual) function and disfigurement. Although injections of alcohol or sclerosing fluids may produce good results, the relief is temporary, and there is always the danger of sloughing. Roentgen
ZAIDENS SH. USE OF DIETHYLSTILBESTROL IN TREATMENT OF KRAUROSIS VULVAE: PRELIMINARY REPORT. Arch Derm Syphilol. 1943;47(5):671–674. doi:10.1001/archderm.1943.01500230061011
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