Ramel1 found acid-fast bacilli in material taken from closed acne lesions of 4 persons in 1928 and of 10 person in 1930, none of whom presented clinical manifestations of tuberculosis. The organisms were verified as Mycobacterium tuberculosis by guinea pig inoculation. R. Griesbach,2 also in 1930, observed acne to be a concomitant finding in more than 30 per cent of 18,000 cases of active pulmonary tuberculosis. Four years later von Kémeri3 found roentgenographic evidence of pulmonary tuberculosis of moderate severity, positive reactions to tuberculin and foci of pyogenic infection in 52 persons with acne. Thirty were treated solely with injections of tuberculin administered in small, gradually increasing doses; in 27 the acne disappeared, in 2 it was improved and in 1 it became worse. Von Kémeri believed that acne resulted from a combined infection with tuberculosis and pyogenic organisms, the former being responsible for the chronicity of
LOEWENTHAL K. SENSITIVITY TO TUBERCULIN IN ACNE AND IN OTHER NONTUBERCULOUS DISEASES OF THE SKIN. Arch Derm Syphilol. 1943;47(6):799–803. doi:10.1001/archderm.1943.01500240039007
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