Among the pharmacodynamic tests used for the study of the physiology of the circulation and peripheral innervation, the histamine test is the most important to the dermatosyphilologist. Its usefulness in the differential diagnosis of certain manifestations of leprosy, syringomyelia, polyneuritis and areas of anesthesia of central origin may be great.
The histamine test, first used by Eppinger and Gutmann in 1913, was studied in relation to the peripheral circulation and its disturbances by Sir Thomas Lewis.1 This test has also been applied to the diagnosis of peripheral neural involvement by Tinel,2 Loesser3 and others and of leprosy by Pierini4 of Buenos Aires, Rodriguez and Plantilla5 of Manila and Schujman6 of Rosario. The test consists, according to Lewis, of intradermal injection of a 1: 1,000 solution of histamine phosphate, the reaction showing in the form of an immediate purpuric spot at the site of the
PARDO-CASTELLO V, TIANT FR. THE HISTAMINE TEST: WITH PARTICULAR REFERENCE TO THE DIAGNOSIS OF LEPROSY. Arch Derm Syphilol. 1943;47(6):826–829. doi:10.1001/archderm.1943.01500240066011
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