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Article
July 1943

ACQUIRED HYPERSENSITIVITY TO THE CHLORINATED ETHYLAMINE VESICANTS: REPORT OF A CASE

Author Affiliations

CINCINNATI

From the Kettering Laboratory of Applied Physiology of the College of Medicine of the University of Cincinnati.

Arch Derm Syphilol. 1943;48(1):15-16. doi:10.1001/archderm.1943.01510010019002
Abstract

In 1935 Ward1 reported briefly on the vesicant qualities of β, β′, β″-trichlorotriethylamine, either as the base or as the hydrochloride. He suggested that with nitrogen compounds three chloroethyl groups are necessary before vesicant action may be noted.

REPORT OF CASE

To test a person known to be very sensitive to bis-β-dichlorodiethylsulfide (mustard agent), β, β′, β″-trichlorotriethylamine hydrochloride was prepared in the manner described by Ward and isolated in the form of clear white crystals. The free amine (β, β′, β″-trichlorotriethylamine) was obtained from the hydrochloride by treating an aqueous solution of the latter with a sodium carbonate solution. The free amine separated as an oil, colored slightly brown but darkened slowly on standing.

The crystals of the hydrochloride were suspended in alcohol (95 per cent) and applied on the flexor surface of the forearm. A drop was applied with a metal

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