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Article
July 1943

VITAMIN A STUDIES IN CASES OF KERATOSIS FOLLICULARIS (DARIER'S DISEASE)

Arch Derm Syphilol. 1943;48(1):17-31. doi:10.1001/archderm.1943.01510010021003
Abstract

In 1941 Peck, Chargin and Sobotka1 published their preliminary report on investigations which led them to the conclusion that keratosis follicularis (Darier's disease) is a vitamin A deficiency syndrome. The present paper embodies extended observations on 10 cases of this disease. Four of the cases were reported in our first paper, and in 3 of them continued observation was possible.

MATERIALS AND METHODS

A quantitative estimation of vitamin A in the blood serum was carried out by Dr. Susan Kann with a photoelectric colorimeter according to the method of Carr and Price.2 The lower normal limits obtained with this method are variously given as 60 to 90 U. S. P. units of vitamin A per hundred cubic centimeters of blood serum. In cases 1, 3, 4, 8 and 9 Dr. Selig Hecht, of the department of biophysics of Columbia University, used his excellent method of determining dark adaptation

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