Recent investigations by Peck and his co-workers1 on Darier's disease (keratosis follicularis) and by Brunsting and Sheard2 on pityriasis rubra pilaris seemed to indicate that disturbances in vitamin A metabolism may reflect themselves in cutaneous changes which have been considered specific dermatologic entities. Unlike the changes in the skin due to A avitaminosis, these changes may occur in cases of the two diseases previously mentioned when there are adequate amounts of vitamin A in the diet.
A rather ambitious program of investigation was undertaken, comprising studies of vitamin A metabolism in cases of diseases of the skin characterized by disturbances in keratinization. Unfortunately, the work has been interrupted by the war and the entrance of one of us into active service. Studies in 2 cases of ichthyosis are here reported.
MATERIALS AND METHODS
Determinations of vitamin A were carried out by Dr. Susan Kann according to the