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Article
July 1943

INTRAVENOUS ADMINISTRATION OF SOBISMINOL SOLUTION: TOXICITY IN NORMAL AND IN SYPHILITIC RABBITS

Author Affiliations

SAN FRANCISCO

From the Department of Pharmacology and Therapeutics, Stanford University School of Medicine.

Arch Derm Syphilol. 1943;48(1):35-41. doi:10.1001/archderm.1943.01510010039005
Abstract

Sollmann and Seifter1 have recently demonstrated that the toxicity of sobisminol solution N. N. R. and of sodium bismuth citrate administered intravenously can be reduced about one-half if the injection is made slowly by a drip method analogous to that proposed for arsenicals in the treatment of syphilis. While the tolerance to antisyphilitic doses of bismuth compounds administered by the drip method was not very gratifying, the question whether the temporary increase in dosage secured in this way was actually more efficient against the spirochetes and in treatment of the lesions seemed worth answering. We were requested by Dr. Sollmann to obtain the answer, if possible, with the use of rabbits with experimental syphilis. We chose sobisminol solution for this purpose because Sollmann and Seifter found this compound to be the least toxic of three bismuth compounds tried intravenously and because of the extensive experience with the drug

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