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Article
August 1943

BENEFICIAL EFFECT OF SMALLPOX VACCINE ON RECURRENT APHTHOUS ULCERS OF MOUTH AND TONGUE

Arch Derm Syphilol. 1943;48(2):151-152. doi:10.1001/archderm.1943.01510020010002

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Abstract

The current methods of treatment of recurrent aphthous ulcers are of little value. I was induced to employ repeated inoculations with smallpox vaccine in 2 cases of aphthous ulcer on the assumption that the condition is probably caused by a virus akin to that of herpes simplex, a disease which, when recurrent, is frequently controlled by such treatment. In both the following cases the disease had been unaffected by local applications of caustic materials or by the use of diets or vitamins.

REPORT OF CASES

Case 1.—V. C., a white man aged 43, was first seen on April 16, 1941. He gave a history of having had "canker sores" in the mouth practically continuously for the preceding two and one-half years. Physical examination showed no abnormalities except for the oral lesions, which consisted of large aphthous ulcers on the inner surface of the lower lip and the left side of

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