Although not the first to describe a peculiar keratotic thickening of the palms and soles associated with the climacteric, Haxthausen1 in 1934 presented a clear description of the eruption and noted its association with other evidences of the climacteric. He applied the term keratoderma climactericum to a "distinct clinical picture consisting of circumscribed hyperkeratosis, mainly of the palms and soles, occurring in women in association with the climacteric and accompanied by various general signs and symptoms, of which obesity and arterial hypertension are those most frequently encountered." This disease had received little attention before Haxthausen's report and even now is not often considered. There have been a few reports of cases, but both the dermatologic textbooks and those on endocrine diseases have given it little attention. Dermatologists should be more familiar with this keratosis, first, because it is more common than is generally realized; second, because its presence indicates
LYNCH FW. KERATODERMA CLIMACTERICUM (HAXTHAUSEN): HYPOESTROGENIC KERATODERMATITIS. Arch Derm Syphilol. 1943;48(3):270–281. doi:10.1001/archderm.1943.01510030023004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: