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Article
September 1943

BLOOD LEVEL AND EXCRETION OF ARSENIC FOLLOWING SINGLE INJECTIONS OF CLORARSEN

Author Affiliations

NASHVILLE, TENN.

This work was made possible through a grant by E. R. Squibb and Sons. From the Department of Medicine, Vanderbilt University School of Medicine.

Arch Derm Syphilol. 1943;48(3):297-301. doi:10.1001/archderm.1943.01510030050007
Abstract

Much has been written concerning the distribution of arsenic in tissues and its excretion after the injection of the several arsphenamines. Fewer data have been published on the blood levels, distribution in the tissues and excretion of arsenoxide. Most of the studies of arsenoxide have been made with reference to "massive dose" therapy. Though there was no reason to suppose that the excretion of clorarsen would differ from that of arsenoxide, it was thought proper that such studies should be made with this drug.

Clorarsen (3 amino-4-hydroxyphenyldichloroarsine hydrochloride) was used a decade and more ago for yaws. Its use in the treatment of syphilis and its toxicity were described in 1941 by Tompsett, Downs, McDermott and Webster.1 Kampmeier and Henning2 have also studied its effect in the treatment of acute syphilis and as an alternate drug to use for persons having untoward reactions to the arsphenamines or

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