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Article
October 1943

THE CHICK EMBRYO ANTIGEN (LYGRANUM) TEST FOR LYMPHOGRANULOMA VENEREUM: A CLINICAL INVESTIGATION

Author Affiliations

CLEVELAND

From the Department of Dermatology and Syphilology, Western Reserve Medical School and Cleveland City and University Hospitals. This work was done under a grant from The Therapeutic Research Committee, Council on Pharmacy and Chemistry, American Medical Association.

Arch Derm Syphilol. 1943;48(4):379-383. doi:10.1001/archderm.1943.01510040023005
Abstract

The purpose of this communication is to report on our experience with a relatively new antigen introduced in 1940 by Grace, Rake and Shaffer1 as being superior to mouse brain antigen for the performance of the Frei test. This antigen (known as lygranum) is made by growing the lymphogranuloma venereum virus in the yolk sac of the developing chick embryo, while lygranum control is made from the yolk sac itself.

In 1941 Sulkin and co-workers,2 using as did the originators of the test a 7 mm. papule as a minimal positive reaction, found in 42 patients with lymphogranuloma venereum 40 with a positive reaction to lygranum and 38 with a positive reaction to human bubo pus. There were easily recognized nonspecific papules in some of the control subjects. The Robinsons3 in 1942 performed simultaneous tests with lygranum and bubo pus on 127 patients. They found 91 per

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