Because of the possibility of some strains of Spirochaeta pallida being particulary virulent, I am reporting the following cases in which syphilis was extremely resistant to treatment in a man but followed a mild course when transmitted to his wife:
J. W. P., aged 30, a white man, was referred to me by Dr. Frank Baxter because of extensive mucous patches in his mouth and a widespread papular secondary eruption. He had had a penile lesion three months previously. The Wassermann reaction of the blood was strongly positive.
Eight weekly injections of mapharsen, 0.06 Gm., along with a bismuth preparation,1 failed to alter the lesions on his skin and in his mouth. After this, he was given old arsphenamine, 0.4 Gm., every three days for six doses without much improvement. Then he was given four more weekly injections of the bismuth preparation plus an injection of typhoid-paratyphoid vaccine to produce
Templeton HJ. RESISTANT SYPHILIS (NONRESISTANT IN WIFE). Arch Derm Syphilol. 1943;48(4):412–413. doi:10.1001/archderm.1943.01510040056010
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