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Article
November 1943

INHIBITORY EFFECT OF MONOCHLORMERCURICARVACROL ON GROWTH OF PATHOGENIC FUNGI

Author Affiliations

LINCOLN, NEB

From the department of bacteriology, University of Nebraska.

Arch Derm Syphilol. 1943;48(5):497-510. doi:10.1001/archderm.1943.01510050021003
Abstract

Many chemicals, inorganic as well as organic compounds, have been suggested as fungistatic and fungicidal agents for the treatment of dermatophytoses commonly referred to as "athlete's foot." The inorganic compounds usually are oxidizing agents (potassium permanganate, iodine, chlorine), acids (boric) or salts of heavy metals (zinc, lead, titanium). The organic compounds recommended have been dyes, organic acids, volatile oils and certain terpene derivatives. The dyes function primarily as bacteriostatic agents; among them are carbolfuchsin and gentian violet. Benzoic and salicylic acids are among the organic acids most frequently employed in ointments. Their copper salts have been reported by Barry, Hartung and Grubb1 to be inferior to the free acids. Clove and cinnamon oils have been recommended; Maplestone,2 however, cautioned against their use because of great variation in fungistatic activity of different batches. Camphor, menthol and thymol are volatile substances which are incorporated in preparations designed to arrest the

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