Physiologic changes in certain areas of the skin at puberty and clinical observations on the skin in cases of eunuchoidism, castration, masculinizing tumors of the ovary and pubertas praecox suggested long ago that sex hormones may in some way be involved in the control of the growth of hair and of the texture of the skin. More recently, as crystalline estrogenic and androgenic substances became available for experimental as well as therapeutic use, efforts were made to disclose effects of these substances on the skin more exactly and in more detail. Thus, valuable information was obtained concerning general effects of estrogenic and androgenic substances on growth of hair in the rat, dog and guinea pig1 as well as in man,2 and on the blood vessels of the skin in man.3
Since the skin is a complex organ and growth of hair a highly complicated process, the
RONY HR, ZAKON SJ. EFFECT OF ANDROGEN ON THE SEBACEOUS GLANDS OF HUMAN SKIN. Arch Derm Syphilol. 1943;48(6):601–604. doi:10.1001/archderm.1943.01510060025002
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