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Article
December 1943

ACANTHOSIS NIGRICANS: IS IT A FORM OF AVITAMINOSIS?

Author Affiliations

PITTSBURGH

From the Pittsburgh Skin and Cancer Foundation.

Arch Derm Syphilol. 1943;48(6):650-655. doi:10.1001/archderm.1943.01510060074010
Abstract

Acanthosis nigricans is a puzzling and rare but distinctive disease of the skin and the mucous membranes. Of its characteristics, it is the striking appearance which has occasioned the many observations which have been made and reported. The characteristic features are changes in pigmentation, both increases and decreases; the appearance of vegetative warty growths; dystrophy and even loss of hair and nails; papillation 1 about the mucocutaneous junctions of the mouth, eyelids, external genitalia and perianal area, and itching of variable character, which at times is unbelievably intense.

As a general rule, two types are recognized. One is the benign juvenile form, which occurs in children and which is usually of little consequence, as it bears no relation to the general well-being. The other is the adult type, which in the vast majority of instances occurs in cachetic persons who suffer from carcinoma of the stomach or intestines, sarcoma, severe

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