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Article
December 1943

THE CHICK EMBRYO ANTIGEN (LYGRANUM) TEST FOR LYMPHOGRANULOMA VENEREUM

Arch Derm Syphilol. 1943;48(6):659. doi:10.1001/archderm.1943.01510060083013
Abstract

To the Editor:—Dr. Heisel and his collaborators1 state that "the originators of the test [used] a 7 mm. papule as a minimal positive [Frei] reaction. . . ." In the report which introduced chick embryo antigen (lygranum) as a material for the Frei test2 it was noted that "the upper limit of the diameter of non-specific papules produced by these materials [lygranum antigens and control] was 5 mm." In the table accompanying that report it is clear that a papule 6 mm. in diameter was regarded as a positive reaction. Support has been given to the selection of this size of papular reaction when lygranum is used as the minimum which can be called positive by the observation3 that in 24 persons in whom the diameter of the papule of the Frei reaction was 6 mm. and who either presented clinical manifestations which could be regarded as lymphogranulomatous or

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