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Article
January 1944

DERMATOLOGIC SIGNIFICANCE OF TISSUE EOSINOPHILIA

Author Affiliations

Fellow in Dermatology and Syphilology, Mayo Foundation; ROCHESTER, MINN.

Arch Derm Syphilol. 1944;49(1):19-26. doi:10.1001/archderm.1944.01510070022005
Abstract

Eosinophilic leukocytes are present in the tissue infiltrate of various dermatologic disturbances. This study was undertaken in an attempt to determine whether there is any relationship between eosinophilia in the tissues and eosinophilia in the blood in some of the dermatologic diseases which cause tissue eosinophilia. In the microscopic study of routine dermatologic sections, at times numerous eosinophils with monolobed1 nuclei are found, while in other sections the eosinophils have nuclei which are bilobed or trilobed. In looking over the literature we found no mention of the relative importance of these two types of eosinophils. Little work apparently has been done to correlate the type of eosinophils with the disease entity.

The earliest reference to the eosinophilic leukocyte is attributed to T. W. Jones,2 who described coarsely granular cells in the blood as early as 1846. In 1861, Förster3 mentioned similar cells in the blood; however,

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