This study has two purposes: The first is to report the results of determinations of the therapeutic effect of sulfanilamide, sulfapyridine, sulfathiazole and sulfadiazine in mice inoculated with Erysipelothrix rhusiopathiae. These drugs were separately employed after the animals were inoculated with the amount of a culture of the organism that normally killed in about four days. The effect of these drugs in conjunction with subcutaneous doses of immune serum was also studied. The second purpose is to discuss the effects of the sulfonamide compounds in the treatment of the infection caused in man by Ery. rhusiopathiae, erysipeloid of Rosenbach.
SULFONAMIDE COMPOUNDS IN TREATMENT OF MICE
Method of Study.—A virulent strain of Ery. rhusiopathiae was obtained from swine skin, the site of "diamond" skin disease1 (a mild form of swine erysipelas2). A section of skin about 3 mm. square was excised and minced in sterile isotonic solution of
KLAUDER JV, RULE AM. SULFONAMIDE COMPOUNDS IN TREATMENT OF ERYSIPELOTHRIX RHUSIOPATHIAE INFECTIONS: EFFECTIVENESS OF SULFANILAMIDE, SULFAPYRIDINE, SULFATHIAZOLE AND SULFADIAZINE AGAINST EXPERIMENTAL INFECTION IN THE MOUSE AND AGAINST ERYSIPELOID OF ROSENBACH IN MAN. Arch Derm Syphilol. 1944;49(1):27–32. doi:10.1001/archderm.1944.01510070030006
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