The macroflocculation test for syphilis (Rappaport and Eichhorn,1 1943) was tried by us because of its merits of simplicity and speediness. Early observations on it in Liverpool have been encouraging and are recorded for possible interest to others. The Meinicke (Meinicke clarification reaction II) macroflocculation test (Meinicke and Grün2 1932) has been performed by us for seven years, and since the war the Meinicke antigen of Ford Robertson and Colquhoun3 (1939) has been used. This test has been satisfactorily sensitive and specific and is simple to perform, but it has the disadvantage of normally requiring sixteen to eighteen hours before results are read.
In the Rappaport and Eichhorn test, drops (0.05 cc.) of the patient's serum and the antigen are mixed and shaken by hand for one-half minute; a similar volume of diluent (sodium phosphate [Na2HPO
HEWISH EA, BARRITT MM. RAPID MACROFLOCCULATION TEST FOR SYPHILIS: METHOD OF RAPPAPORT AND EICHHORN. Arch Derm Syphilol. 1944;49(4):240–241. doi:10.1001/archderm.1944.01510100016004
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