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Article
May 1944

CONCENTRATION OF ARSENIC IN BLOOD AFTER ADMINISTRATION OF MAPHARSEN BY RAPID DRIP METHOD: CLINICAL AND EXPERIMENTAL STUDIES

Author Affiliations

Director, Social Hygiene Division of the Detroit Department of Health DETROIT

From the Research Laboratories, Parke, Davis & Company.

Arch Derm Syphilol. 1944;49(5):321-326. doi:10.1001/archderm.1944.01510110019005
Abstract

Various methods have been used for the administration of mapharsen in an effort to maintain a maximum therapeutic level of arsenic in the blood stream and thus shorten the period of treatment. Leifer, Chargin and Hyman1 used the slow continuous drip method; Thomas and Wexler,2 the rapid, or syringe, method, and Shaffer,3 a one hour rapid continuous drip method. Sobotka, Mann and Feldbau4 studied and reported the concentrations of arsenic in the blood of patients for whom the slow continuous drip method of administration was used. Siegel, Goldstein and Goldwater5 reported results of similar studies with the rapid, or syringe, method. The present report is the result of similar studies on Shaffer's method made for the purpose of comparison with the other two methods of administration.

Certain data for dogs are included for the purpose of comparison with those obtained in the clinical

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