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Article
May 1944

ASYMMETRIC CUTANEOUS LESIONS IN PELLAGRA

Author Affiliations

ICAL CORPS, ARMY OF THE UNITED STATES; CINCINNATI

The expenses of this study were defrayed by grants from The John and Mary R. Markle Foundation and Standard Brands, Incorporated.

University of Cincinnati Studies in Nutrition at the Hillman Hospital, Birmingham, Ala. From the Department of Internal Medicine, University of Cincinnati.

Arch Derm Syphilol. 1944;49(5):335-345. doi:10.1001/archderm.1944.01510110033009
Abstract

Besides giving a name to the syndrome, the cutaneous lesions of pellagra have excited the admiration and stimulated the speculations of many generations of pellagrologists. Indeed, the speculations have often taken the place of thoughtful study of the exanthem, or pellagraderm. Several factors have delayed advance in knowledge. In times past, the diagnosis of pellagra was ventured rarely except in the presence of well established lesions of the skin. Thus, the study was preponderantly of end results, since dermatitis is uncommon in mild and early deficiency. It is now known that the changes in the skin may be indolent and that they do not necessarily parallel the severity of the disease. The demonstration by Spies1 that glossitis is a much more sensitive gage than dermatitis in evaluation of therapeutic measures has properly turned the emphasis in early diagnosis from the skin. As a corollary, it has

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